The offspring of the two hundred, the Nephilim, were a poisoned fruit.  The whole world will become sick, and God will need to disinfect the earth.  On day three of creation, God willed that dry land should appear.  Similarly, He will cause the dry land to disappear by means of a planetwide flood lasting one year (Genesis 6:17).  The only survivors will be the occupants of an ark made of wood which God will provide the designs for.  The Nephilim will also be wiped out by the flood but will appear again later (Genesis 6:4).  The former won't survive God’s judgment by hanging on to the side of the ark.  They had ravenous appetites and could only sustain themselves by consuming the ark’s inhabitants.  They also won’t find refuge in the center of the earth.  This is where some of the water for the flood will come from.  However, the giants will reemerge due to the repeated human desire for knowledge and power.